Ketamine infusion therapy represents a promising frontier in addiction treatment, particularly for individuals grappling with severe substance use disorders. This innovative approach involves administering controlled doses of ketamine, a dissociative anesthetic, in a clinical setting under medical supervision. Ketamine's unique ability to modulate glutamate neurotransmission and enhance synaptic plasticity has shown potential in resetting neural pathways disrupted by addiction. Research suggests that ketamine infusion therapy can alleviate withdrawal symptoms, reduce cravings, and provide a window of opportunity for individuals to engage more effectively in traditional therapies such as counseling and behavioral interventions. While still under investigation and not without controversy, ketamine infusion therapy offers a glimpse of hope for those who have not responded well to conventional treatment methods, offering a novel pathway towards recovery from addiction.